麻黄化学成分与药理作用研究进展Advances in research of chemical constituents and pharmacological activites of Ephedra
丁丽丽;施松善;崔健;王顺春;王峥涛;
DING Li-li~(1,2),SHI Song-shan~(1,2),CUI Jian~(1,2),WANG Shun-chun~(1,2),WANG Zheng-tao~(1,2)(1.Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Key Laboratory of Standardization of Chinese Medicines Ministry of Education,Shanghai 201203,China;2.Shanghai R&D Center for Standardization of Traditional Chinese Medicines,Shanghai 201203,China)
摘要(Abstract):
综述了麻黄属中生物碱、黄酮、挥发油、有机酸、氨基酸、多糖和鞣质等7大类化学成分的研究结果,并介绍了近年来发现的麻黄糖尿病相关活性、抗凝血、降压、免疫抑制、抗氧化及抗病毒等新的药理活性,为我国丰富麻黄资源的开发利用提供了新的思路。
The collected information is an attempt to cover the more recent developments in the phytochemistry and pharmacology of this genus.During the past years,alkaloids,flavonoids,volatile oils,organic acids,polysaccharides,tannins and phenolic constituents have been isolated from Ephedra.Pharmacological studies are described according to hypoglycemic effects,anticoagulated blood properties,depressurization,immunosuppressive activity,antioxidation and antivirus activity and so on.The information summarized here is intended to provid a rational foundation for the futher development and utilization of Ephedra which is rich in China.
关键词(KeyWords):
麻黄;化学成分;药理作用
Ephedra;chemical constituent;pharmacological activity
基金项目(Foundation): 上海市重点学科建设资助项目(Y0301)
作者(Author):
丁丽丽;施松善;崔健;王顺春;王峥涛;
DING Li-li~(1,2),SHI Song-shan~(1,2),CUI Jian~(1,2),WANG Shun-chun~(1,2),WANG Zheng-tao~(1,2)(1.Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Key Laboratory of Standardization of Chinese Medicines Ministry of Education,Shanghai 201203,China;2.Shanghai R&D Center for Standardization of Traditional Chinese Medicines,Shanghai 201203,China)
Email:
DOI:
参考文献(References):
- [1]姜海楼,史家振,石壮沙,等.麻黄综合研究Ⅰ麻黄史料考证[J].哲里木畜牧学院学报,1996,6(2):31.
- [2]NawwarM A M,Barakat H H,Buddrust J,et al.A lkaloidal,lignan and phenolic constituents ofEphedra alata[J].Phyto-chem istry,1985,24(4):878.
- [3]StarrattA N,Caveney S,Qu inoline-2-carboxylic acids fromEphe-draspecies[J].Phytochem istry,1996,42:1477.
- [4]A l-Khalil S,A lkofah i A,E l-E isaw i D,et al.Transtorine,a newqu inoline alkaloid fromEphedra transtoria[J].J Nat Prod,1998,61(2):262.
- [5]Purev O,Posp isil F,Motl O.Flavonoids fromEphedra sinicastapf[J].Collect Czech Chem Commun,1988,53(12):3193.
- [6]Mahmoud A M N,Hassan I E,Heba H B.Flavonoid constituentsofEphedra alata[J].Phytochem istry,1984,23(12):2937.
- [7]Sahar A M H,Heba H B,Mahmoud A M N,et al.FlavonoidsfromEphedra aphylla[J].Phytochem istry,1997,45(7):1529.
- [8]Tsitsa-Tzard i E,Louk is A,Ph ilianos S.Polyphenolic compoundsofEphedra campylopoda[J].F itoterap ia,1987,58(3):200.
- [9]吉力,徐灵植,潘炯光,等.草麻黄中麻黄和木贼麻黄挥发油化学成分的GC-MS分析[J].中国中药杂志,1997,22(8):489.
- [10]文洁,陆学筠,韦英.丽江麻黄化学成分的研究[J].中药材,1997,20(10):512.
- [11]A lvin N S,Stan ley C.Cyclopropane am ino acids fromEphedra[J].Phytochem istry,1995,40(2):479.
- [12]张建中,敖特根,苏日娜.麻黄果营养成分和利用价值的初步研究[J].内蒙古林学院学报,1997,19(3):50.
- [13]Konno C,M izuno T,H ik ino H.Isolation and hypoglycem ic ac-tivity of ephedrans A,B,C,D and E,G lycsns ofEphedra D is-tachyaHerbs[J].P lanta M ed,1985,2:162.
- [14]王书华,李如章,曾淑萍,等.麻黄果实多糖含量的测定[J].张家口医学院学报,1999,16(2):23.
- [15]R iclo R A,Sena G A,Vai V M,et al.D eterm ination of thepresence of condensed tann ins inEphedra am ericanaHumb.etBonpl.exW ild[J].Actva Farm Bonaerense,2004,23(1):11.
- [16]Cottiglia F,Bonsignore L,Casu L.Phenolic constituents fromEphe-dra nebrodeusis[J].Nat Prod Res,2005,19(2):117.
- [17]X iu L M,M iura A B,Yamamoto K,et al.Pancreatic islet re-generation by ephedrine in m ice w ith streptozotocin-induced d ia-betes[J].Am J Ch in M ed,2001,29(3-4):493.
- [18]蒋明,高久武司,奥田拓道.麻黄胰岛素样作用的实验研究[J].中国药学杂志,1997,32(12):782.
- [19]蒋明,高久武司,奥田拓道.麻黄对脂肪细胞脂质代谢影响的实验研究[J].中国中药杂志,1999,24(5):302.
- [20]邱丽颖,王书华,吕莉,等.麻黄果多糖的抗凝血机制研究[J].张家口医学院学报,1999,16(1):3.
- [21]邱丽颖,王书华,吕莉,等.麻黄果多糖对家兔动脉血压的影响机制研究[J].张家口医学院学报,1999,16(2):1.
- [22]陈荣明,朱耕新,许银芝.麻黄中不同提取物对细胞免疫的影响[J].南京中医药大学学报,自然科学版,2001,17(4):234.
- [23]Saito S Y,Maruyama Y,Kam iyama S,et al.Ephedrae herba inMao-Bush i-Saish in-To inh ib its IgE m ed iated h istam ine releaseand increases cAMP content in RBL-2H3 cells[J].J PharmacolSci,2004,95(1):41.
- [24]Kobayash i K,Saito Y,Nakazawa I,et al.Screen ing of crudedrugs for influence on amylase activity and postprand ial b lood glu-cose in mouse plasma[J].B iol Pharm Bu ll,2000,23(10):1250.
- [25]张连茹,邹国林,杨天鸣.麻黄水溶性多糖的提取及其清除氧自由基作用的研究[J].氨基酸与生物资源,2000,22(3):24.
- [26]Okawa M,K in jo J,Nohara T,et al.DPPH(1,1-d iphenyl-2-p icrylhydrazyl)rad ical scavenging activity of flavonoids obtainedfrom som e m ed icinal plants[J].B iol Pharm Bu ll,2001,24(10):1202.
- [27]Mantan i N,Iman ish i N,Kawamata H,et al.Inh ib itory effect of(+)-catech in on the growth of influenza A/PR/8 virus in MD-CK cells[J].P lanta M ed,2001,67(3):240.
- [28]Sato Y,Ohta S,SakuraiN,et al.Stud ies on chem ical protectorsagainst rad iation.XXVI.Protective effect of various extracts oncrude drugs on sk in in jury induced by X-irrad iation[J].Yaku-gaku Zassh i,1989,109(2):113.
- [29]Takara K,Horibe S,Obata Y,et al.E ffects of 19 herbal ex-tracts on the sensitivity to paclitaxel or 5-fluorouracil in Hela cells[J].B iol Pharm Bu ll,2005,28(1):138.
- [30]CA.2005,142,245644 s.
- 丁丽丽
- 施松善
- 崔健
- 王顺春
- 王峥涛
DING Li-li~(1- 2)
- SHI Song-shan~(1
- 2)
- CUI Jian~(1
- 2)
- WANG Shun-chun~(1
- 2)
- WANG Zheng-tao~(1
- 2)(1.Institute of Chinese Materia Medica
- Shanghai University of Traditional Chinese Medicine
- Key Laboratory of Standardization of Chinese Medicines Ministry of Education
- Shanghai 201203
- China
- 2.Shanghai R&D Center for Standardization of Traditional Chinese Medicines
- Shanghai 201203
- China)
- 丁丽丽
- 施松善
- 崔健
- 王顺春
- 王峥涛
DING Li-li~(1- 2)
- SHI Song-shan~(1
- 2)
- CUI Jian~(1
- 2)
- WANG Shun-chun~(1
- 2)
- WANG Zheng-tao~(1
- 2)(1.Institute of Chinese Materia Medica
- Shanghai University of Traditional Chinese Medicine
- Key Laboratory of Standardization of Chinese Medicines Ministry of Education
- Shanghai 201203
- China
- 2.Shanghai R&D Center for Standardization of Traditional Chinese Medicines
- Shanghai 201203
- China)