中国中药杂志

2021, v.46(20) 5173-5184

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中药及其外用制剂调控细胞因子促创面愈合的研究进展
Research progress on role of Chinese medicinal materials and their topical preparations in wound healing by regulating cytokines and growth factors

杨露;张永萍;彭丽华;
YANG Lu;ZHANG Yong-ping;PENG Li-hua;Guizhou Provincial Research Center of Ethnic Medicine Processing and Preparation Technology, National Engineering Research Center of Miao′s Medicines, School of Pharmacy, Guizhou University of Traditional Chinese Medicine;College of Pharmaceutical Sciences, Zhejiang University;State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology;

摘要(Abstract):

创伤、外科手术、急性疾病或慢性疾病引起的伤口延迟愈合或不愈,以及增生的瘢痕,给患者的生理健康、心理和家庭经济造成了沉重的负担。如何加速创面愈合及获得满意的美学效果是临床亟待解决的问题。创面愈合包括止血、炎症、增殖和重塑过程,该过程涉及多种细胞因子参与。近年来,中药通过调控细胞因子对加速创面愈合,抑制疤痕形成等机制得到了逐步阐明,为中药在临床创伤的疗效提供了科学依据。该文重点回顾和总结了中药有效成分、提取物及其外用制剂通过调节细胞因子在创面愈合炎症、增殖、重塑阶段发挥的治疗作用及起效机制,并对未来的研究及应用提出建议与展望,以期为中药用于加速创面愈合等研究与应用提供依据与参考。
Delayed-or non-healing wounds caused by trauma, surgical procedures, acute diseases, or chronic diseases, and proli-ferating scar have a serious impact on patients′ quality of life and increase the economic and psychological burden on their families. Therefore, how to accelerate wound healing and obtain satisfactory aesthetic results is of great concern to researchers and is an urgent clinical problem to be solved. In recent years, the mechanisms of Chinese medicinal materials in accelerating wound healing and inhi-biting scar formation by regulating cytokines have been clarified, which provides a scientific basis for revealing the efficacy of Chinese medicinal materials against clinical trauma. This review focuses on the therapeutic effects of active ingredients, extracts, and topical preparations of Chinese medicinal materials through regulating cytokines in the inflammation, proliferation, and remodeling phases of wound healing. It is expected to provide evidence for the application of Chinese medicinal materials in wound therapy.

关键词(KeyWords): 创面愈合;中药;外用制剂;细胞因子;生长因子
wound healing;Chinese medicinal material;topical preparation;cytokines;growth factor

Abstract:

Keywords:

基金项目(Foundation): 国家苗药工程技术研究中心项目(2014FU125Q09);; 贵州省高层次创新型人才“百层次”人才项目(黔科合平台人才[2015]4030);; 贵州省教育厅研究生创新计划项目(黔教合YJSCXJH[2020]156);; 国家重点研发计划项目(2018YFC1105404);; 中央本级重大增减支项目(2060302);; 中国澳门特别行政区澳门科技发展基金项目

作者(Author): 杨露;张永萍;彭丽华;
YANG Lu;ZHANG Yong-ping;PENG Li-hua;Guizhou Provincial Research Center of Ethnic Medicine Processing and Preparation Technology, National Engineering Research Center of Miao′s Medicines, School of Pharmacy, Guizhou University of Traditional Chinese Medicine;College of Pharmaceutical Sciences, Zhejiang University;State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology;

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