中国中药杂志

2008, (08) 973-976

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泡腾技术在药物制剂中的研究进展
Review of effervescent technique in pharmaceutics research

罗晓健;辛洪亮;饶小勇;肖志强;高丽丽;孙婷婷;郭琦丽;
LUO Xiao-jian1,2,XIN hong-liang2,RAO xiao-yong2,XIAO Zhi-qiang2,GAO Li-li2,SUN Ting-ting2,GUO Qi-li(1.Nationl Pharmaceutical Engineering Center for Soild Preparation in Chinese Herbal Medicine,Nanchang 330006,China;2.Jiangxi University of Traditional Chinese Medicine,Nanchang 3300006,China)

摘要(Abstract):

泡腾技术作为加快制剂崩解,促进药物溶出的技术,常用于速释制剂中,随着相关技术与理论研究深入,泡腾技术越来越广泛应用于缓控释制剂和脉冲释药系统中,调节释药制剂行为。作者主要介绍了泡腾技术在泡腾片、胃漂浮制剂、渗透泵片和脉冲释药系统中研究应用,以及泡腾制剂共性关键技术研究进展,有利于泡腾制剂研究与开发。
Effervescent technique,which can accelerate drug disintegration and dissolution,is usually applied in quick release preparations.Along with the development of pharmaceutical technique and theory,effervescent technique is used more and more extensively to adjust the behavior of drug release,such as in sustained and controlled release preparations,pulsatile drug delivery systems,and so on.This review demonstrated the new applying of effervescent technique in effervescent tablets,stomach floating forms,osmotic pump tablets and pulsatile drug delivery systems,adding to the critical common technique of effervescent forms in drug research.This will be benefit for the further research and development of effervescent technique.

关键词(KeyWords): 泡腾技术;泡腾片;胃内漂浮制剂;渗透泵片;脉冲释药制剂
effervescent technique;effervescent tablets;stomach floating forms;osmotic pump tablets;pulsatile drug delivery systems

Abstract:

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基金项目(Foundation): 国家科技支撑计划项目(2006BA109B07-06)

作者(Author): 罗晓健;辛洪亮;饶小勇;肖志强;高丽丽;孙婷婷;郭琦丽;
LUO Xiao-jian1,2,XIN hong-liang2,RAO xiao-yong2,XIAO Zhi-qiang2,GAO Li-li2,SUN Ting-ting2,GUO Qi-li(1.Nationl Pharmaceutical Engineering Center for Soild Preparation in Chinese Herbal Medicine,Nanchang 330006,China;2.Jiangxi University of Traditional Chinese Medicine,Nanchang 3300006,China)

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