中国中药杂志

2008, v.33(23) 2768-2771

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黄芪生脉胶囊与组方药材指纹图谱色谱峰相关性研究
Correlativity between fingerprint peaks of HQSM capsule and its relevant herbs

陈建真;吕圭源;陈素红;叶磊;
CHEN Jian-zhen1,LV Gui-yuan1,CHEN Su-hong2,YE Lei1(1.Zhejiang Chinese Medical University,Hangzhou 310053,China;2.Wenzhou Medicinal College,Wenzhou 325035,China)

摘要(Abstract):

目的:建立黄芪生脉胶囊HPLC指纹图谱,并研究复方与组方药材指纹图谱色谱峰相关性。方法:通过HPLC-DAD联用建立复方及各药材指纹图谱,以色谱峰保留时间和紫外光谱信息为考察指标,对复方指纹图谱色谱峰归属进行分析。结果:建立了有16个特征峰的HPLC指纹图谱,对复方特征峰进行了归属分析,确定了特征峰的药材归属。结论:该方法有助于提高黄芪生脉胶囊的质量控制水平,能较好地判别复方主要色谱峰与药材化学组分间的相关性,可应用于中药复方化学组成及来源分析。
Objective: To establish HPLC fingerprint of HQSM capsules,and a new method for correlativity analysis between fingerprint peaks of HQSM and its relevant herbs based on the fingerprint analysis.Method: The chromatographic fingerprints of HQSM and its relevant herbs were analyzed by HPLC configured with DAD.The similarity of the HPLC fingerprints between HQSM and its relevant herbs and the comparison of UV spectra of the main peaks in both of fingerprints were used as indices to evaluate the correlativity.Result: The HPLC fingerprint with 16 common peaks was established and the chromatographic peaks were determined.Conclusion: The established method effectively controlled the quality of HQSM and establised the correlativity between HQSM and its relevant herbs,which would contribute to deduce the chemical components or sources of traditional Chinese medicine prescription.

关键词(KeyWords): 黄芪生脉胶囊;指纹图谱;相关性研究;相似度评价
HQSM capsules;HPLC fingerprint;correlativity;simalityD

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基金项目(Foundation): 国家863计划项目(2003AA2Z3262)

作者(Author): 陈建真;吕圭源;陈素红;叶磊;
CHEN Jian-zhen1,LV Gui-yuan1,CHEN Su-hong2,YE Lei1(1.Zhejiang Chinese Medical University,Hangzhou 310053,China;2.Wenzhou Medicinal College,Wenzhou 325035,China)

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