中国中药杂志

2021, v.46(06) 1311-1331

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葛属植物的化学成分及药理活性研究进展
Research advances in chemical constituents and pharmacological activities of Pueraria genus

朱卫丰;李佳莉;孟晓伟;张普照;吴文婷;刘荣华;
ZHU Wei-feng;LI Jia-li;MENG Xiao-wei;ZHANG Pu-zhao;WU Wen-ting;LIU Rong-hua;Key Laboratory of Modern Chinese Medicine Preparations,Ministry of Education,Jiangxi University of Traditional Chinese Medicine;

摘要(Abstract):

豆科蝶形花亚科葛属植物作为中国、日本、韩国、印度和泰国等国家常用药,药用历史悠久,分别载录于《中国药典》《日本药典》《韩国药典》《印度阿育吠陀药典》和《泰国植物志》等。全球现有葛属植物15~20种,我国有7种加2变种,目前具有药用价值的主要有葛根、粉葛等6种;该属植物主要化学成分为异黄酮类、黄酮类、萜类、甾体类、香豆素类、葛酚苷类和苯并吡喃类等,目前已从该属植物中分离鉴定出240个化合物,其药理作用主要有改善心血管系统、抗氧化、降血糖、解热、抗炎、解酒护肝和雌激素样作用等。该研究对国内外药用葛属植物的化学成分及药理活性等进行了系统总结,以期为该属植物的药效物质基础、质量控制及深入开发研究提供参考。
Kudzu plants in the subfamily sphenoideae of Leguminosae are commonly used herbs in China, Japan, Korea, India and Thailand, with a long history of medicinal use. They are recorded in Chinese Pharmacopoeia, Japanese Pharmacopeia, Korea Pharmacopeia, Ayurveda Pharmacopoeia of India and Flora of Thailand. There are 15-20 species of Pueraria in the world, including 7 species and 2 varieties in China. At present, there are 6 species with medicinal value, such as Pueraria lobata and P. thomsonii. The main chemical components of the genus are isoflavones, flavonoids, terpenes, steroids, coumarins, puerarin glycosides and benzopyrans. A total of 240 compounds have been isolated and identified from this genus, and their pharmacological effects mainly include improvement of the cardiovascular system, antioxidant, hypoglycemic, antipyretic, anti-inflammatory, anti-alcoholic and estrogen-like effects. In this study, chemical constituents and pharmacological activities of Pueraria at home and abroad were systematically summarized, in order to provide references for the material basis, quality control and further development of Pueraria genus.

关键词(KeyWords): 葛属植物;化学成分;药理活性;葛根;粉葛
Pueraria genus;chemical constituent;pharmacological activity;P.lobata;P.thomsonii

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2017YFC1702902);; 江西中医药大学重点学科青年教师培养计划项目(2017jzzdxk019)

作者(Author): 朱卫丰;李佳莉;孟晓伟;张普照;吴文婷;刘荣华;
ZHU Wei-feng;LI Jia-li;MENG Xiao-wei;ZHANG Pu-zhao;WU Wen-ting;LIU Rong-hua;Key Laboratory of Modern Chinese Medicine Preparations,Ministry of Education,Jiangxi University of Traditional Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20201124.601

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