中国中药杂志

2018, v.43(04) 684-688

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黄芩苷药代动力学研究进展
Advance in studies on pharmacokinetics of baicalin

周红潮;杜锐;王慧;曾范利;时坤;李建明;宗颖;
ZHOU Hong-chao;DU Rui;WANG Hui;ZENG Fan-li;SHI Kun;LI Jian-ming;ZONG Ying;College of Chinese Medicine Materials,Jilin Agricultural University;Key Laboratory of Animal Production,Product Quality and Security,Ministry of Education of the People's Republic of China,Laboratory of Production and Product Application of Sika Deer of Jilin Province;

摘要(Abstract):

黄芩是中国的传统中药材,其主产于河北、山东等地,具有解热、抗菌、抗炎、抗氧化等药理作用。黄芩苷是黄芩的主要活性成分,但是黄芩苷生物利用度低,制约了黄芩在临床上的使用。近年来,国内外对黄芩苷在体内代谢动态规律开展了大量研究,该文通过对黄芩苷及其复方药物中黄芩苷的药代动力学研究进展进行综述,并总结黄芩苷研究现状,旨在为黄芩苷进一步的研究提供科学依据。
Scutellariae baicalensis is one of the most important traditional Chinese medicinal herbs,mainly distributed in Shandong and Hebei provinces. It has significant pharmacological effects such as antimicrobial activity,anti-inflammatory and antioxidation. Baicalin is one of its main effective components. However,baicalin's low bioavailability has restricted its clinical application. In recent decades,extensive studies have been carried out on the metabolism of baicalin in vivo at home and abroad. In order to provide scientific references for baicalin's further studies,this paper would not only review the advances in pharmacokinetics research of baicalin and Chinese herbal preparations containing baicalin,but also make a summary on research status of baicalin.

关键词(KeyWords): 黄芩苷;生物利用度;药代动力学;中药
baicalin;bioavailability;pharmacokinetics;traditional Chinese medicine

Abstract:

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基金项目(Foundation): 国家自然科学基金青年基金项目(31502109);; 吉林省科技厅科技支撑计划项目(20160209006YY);吉林省科技厅重点科技攻关项目(20150204028NY)

作者(Author): 周红潮;杜锐;王慧;曾范利;时坤;李建明;宗颖;
ZHOU Hong-chao;DU Rui;WANG Hui;ZENG Fan-li;SHI Kun;LI Jian-ming;ZONG Ying;College of Chinese Medicine Materials,Jilin Agricultural University;Key Laboratory of Animal Production,Product Quality and Security,Ministry of Education of the People's Republic of China,Laboratory of Production and Product Application of Sika Deer of Jilin Province;

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