中国中药杂志

2020, v.45(12) 2903-2906

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赤芍中的1个新木脂素苷类化合物
A new lignan glucoside from root of Paeonia lactiflora

钟万超;李瑞;夏欢;夏桂阳;张景芳;田贵华;林生;
ZHONG Wan-chao;LI Rui;XIA Huan;XIA Gui-yang;ZHANG Jing-fang;TIAN Gui-hua;LIN Sheng;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine;

摘要(Abstract):

通过正相硅胶、凝胶、大孔吸附树脂和反相HPLC多种色谱技术,从赤芍水提取物中分离得到1个新木脂素苷(1),经UV,IR,HRESI-MS,CD,1D和2D NMR波谱学方法以及化学方法鉴定其结构为(+)-肉豆蔻素A_2-4-O-β-D-吡喃葡萄糖苷。化合物1对LPS诱导的RAW264.7细胞NO的释放具有较强的抑制活性,IC_(50)为21.3μmol·L~(-1)。
A new lignan glucoside,(+)-fragransin A_2-4-O-β-D-glucopyranoside(1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis(MS, UV, IR, CD, 1 D and 2 D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC_(50) value of 21.3 μmol·L~(-1).

关键词(KeyWords): 赤芍;化学成分;木脂素苷;NO抑制活性
Paeonia lactiflora;chemical constituents;lignan glucoside;NO inhibition activity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81773589,81522050);; 中国医学科学院医学与健康科技创新工程项目(2017-IZM-3-010);; 国家“重大新药创制”科技重大专项(2018ZX09711001-001)

作者(Author): 钟万超;李瑞;夏欢;夏桂阳;张景芳;田贵华;林生;
ZHONG Wan-chao;LI Rui;XIA Huan;XIA Gui-yang;ZHANG Jing-fang;TIAN Gui-hua;LIN Sheng;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine;

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