中国中药杂志

2006, (08) 621-624

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代谢组学在中医药复杂理论体系研究中的应用
Application of metabonomics in complicated theory system research of traditional Chinese medicine

贾伟;蒋健;刘平;赵立平;陈闽军;周明眉;杨丽萍;王米渠;邱明丰;张永煜;
JIA Wei~1,LIU Ping~2,JIANG Jian~2,CHEN Min-jun~1,ZHAO Li-ping~1,ZHOU Ming-mei~2,YANG Li-ping~3,WANG Mi-qu~3,QIU Mingfeng~1,ZHANG Yong-yu~2(1.Shanghai Institute for System Biology,Shanghai Jiao Tong University,Shanghai 200030,China;2.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China3.Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

摘要(Abstract):

新兴学科代谢组学的出现,给中医药复杂理论体系的研究、中医药现代化提供了强有力的研究手段。中医病证引起代谢物组的共性分析和生物标记物的发现,可促进“证”本质的研究、中医辨证的科学化和定量化,深层次理解中医脏象理论,预测疾病的发生,整体性评价中药复方综合疗效、安全性和作用机制,反应肠道内生态环境状况。代谢组学和中医药学的结合,将探索出中医药复杂理论体系研究的新方法与新途径。
Metabonomics,a new and rapid-developing technology,will be powerful means to the research of complexed theory system and modernization of traditional Chinese medicine(TCM).Discovery of biomarkers and analysis of common properties from the metabolome of a specific TCM syndrome will facilitate the modernized study of TCM system,promote the quantitative and scientific elucidation of TCM syndrome differentiation,provide an in-depth understanding of the TCM theory of Zang-xiang,help predict the disease on-set,and achieve a comprehensive evaluation of systemic clinical efficacy,safety and mechanism of action of the TCM combination formulas along with a better understanding of intestinal microflora ecology.The new approach with combined metabonomics and TCM methodologies will provide a new pathway and methodology for the study of complicated theory system of TCM and its modernization.

关键词(KeyWords): 代谢组学;中医药复杂理论系统;辨证论治;脏象理论;中药方剂;肠道菌群微生态学
metabonomics;complexed theory system of TCM;treatment based on syndrome differentiation;Zang-xiang theory;intestinal microflora ecology

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作者(Author): 贾伟;蒋健;刘平;赵立平;陈闽军;周明眉;杨丽萍;王米渠;邱明丰;张永煜;
JIA Wei~1,LIU Ping~2,JIANG Jian~2,CHEN Min-jun~1,ZHAO Li-ping~1,ZHOU Ming-mei~2,YANG Li-ping~3,WANG Mi-qu~3,QIU Mingfeng~1,ZHANG Yong-yu~2(1.Shanghai Institute for System Biology,Shanghai Jiao Tong University,Shanghai 200030,China;2.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China3.Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

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