中国中药杂志

2021, v.46(20) 5226-5232

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补阳还五汤对脑缺血后神经血管单元影响的研究进展
Effects of Buyang Huanwu Decoction on neurovascular units after cerebral ischemia: a review

郑晓宇;张业昊;宋文婷;曹慧;刘建勋;
ZHENG Xiao-yu;ZHANG Ye-hao;SONG Wen-ting;CAO Hui;LIU Jian-xun;Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences;Beijing University of Chinese Medicine;

摘要(Abstract):

补阳还五汤是中医药益气活血的代表方,在临床急性脑梗死防治中有着良好的成效,由黄芪、当归尾、赤芍、地龙、川芎、红花、桃仁组成,具有多种中药有效成分。神经血管单元是一个功能上和结构相互依存的多细胞复合体,由神经元-胶质细胞-血管构成,在研究脑缺血的病理变化和血脑屏障通透性方面有着重要的作用。近年来补阳还五汤多被发现可以通过保护神经血管单元的完整性和改善血脑屏障的通透性,进而改善脑缺血所致的脑卒中等疾病。该文对补阳还五汤保护神经血管单元这一方面进行了总结和整理。
Buyang Huanwu Decoction, a representative prescription in traditional Chinese medicine(TCM) for tonifying Qi and activating blood, has been proved to be effective in preventing and treating acute cerebral infarction(ACI). It consists of Astragali Radix, Angelicae Sinensis Radix, Paeoniae Radix Rubra, Pheretima, Chuanxiong Rhizoma, Carthami Flos, and Persicae Semen, possessing multiple active ingredients. The neurovascular unit is a functionally and structurally interdependent multicellular complex composed of neurons-glial cells-blood vessels. It plays an important role in the pathological changes of cerebral ischemia and the permeability variation of the blood-brain barrier. In recent years, Buyang Huanwu Decoction has been found to protect the integrity of neurovascular units and improve the permeability of the blood-brain barrier, thereby alleviating stroke and other diseases caused by cerebral ischemia. This paper collated and summarized the protective effects of Buyang Huanwu Decoction on neurovascular units.

关键词(KeyWords): 补阳还五汤;神经血管单元;脑缺血;血脑屏障
Buyang Huanwu Decoction;neurovascular unit;cerebral ischemia;blood-brain barrier

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(8203000944);; 国家重点基础研究发展计划(973)项目(2015CB554405)

作者(Author): 郑晓宇;张业昊;宋文婷;曹慧;刘建勋;
ZHENG Xiao-yu;ZHANG Ye-hao;SONG Wen-ting;CAO Hui;LIU Jian-xun;Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences;Beijing University of Chinese Medicine;

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